WebMutations in CTNNB1 occur at relatively high frequency in endometrial cancer and hepatocellular carcinoma, which are known to express high TTK levels. We propose … WebIn addition, TTK was overexpressed in different solid tumor types, suggesting its importance in cancer progression (SI Appendix, Fig. S1). Further, OncoPrint analysis showed that TTK over-expression was the most significantly associated with mutations and deletions in TP53 and PTEN, the two commonly altered tumor suppressor genes and negative cell-cycle …
TTK inhibitor promotes radiosensitivity of liver cancer cells …
WebFeb 25, 2024 · Cancer-testis antigens (CTAs) are often expressed in tumor and testicular tissues but not in other normal tissues. To date, there has been no comprehensive study of the expression and clinical significance of CTA genes associated with endometrial cancer (EC) development. Additionally, the clinical relevance, biological role, and molecular … WebSep 12, 2024 · Increase in TTK expression and its correlation with higher tumor grade, triple negative status, and worse overall survival in breast cancer.a–d Box plots of TTK gene … binary of 8
Treadwell Therapeutics Advances Phase I TTK Inhibitor to Breast Cancer …
WebApr 23, 2024 · Besides, the TTK expression is significantly increased in liver cancer [8,9]. Moreover, TTK was reported to promote cell proliferation and migration in liver cancer [10]. These results suggested that TTK may serve as a potential target in liver cancer therapy. TTK inhibitors effectively and selectively inhibit Mps1, and some of them are applied ... WebAug 1, 2015 · TTK inhibitors are anticipated to be more active in SAC dependent tumors and data in the literature suggests that triple negative breast cancer is among the tumor types potentially highly dependent on TTK activity. Moreover, in accelerating mitosis, TTK inhibitors have a novel mode of action as compared to currently known mitotic inhibitors. WebSep 13, 2016 · The identification of TTK as a novel cancer-testis antigen (CTA) 25,26 allows development as potential target in the setting of anti-cancer immunotherapy, given that expression is restricted ... binary of 85