Webb12 juli 2024 · Triple-negative breast cancer (TNBC) is an aggressive disease with dismal clinical outcome due to limited therapeutic options 1, 2. Immune checkpoint blockade … Webb5 apr. 2024 · In triple-negative breast cancers (TNBC), which is reported to be the most immunogenic sub-type, the immune escape is related to the development of the immunosuppressive tumor microenvironment. [9] Immunogenicity of Breast Cancer Identification of tumor antigen by the immune system triggers anti-tumor immunity and …
Heat‐Confined Tumor‐Docking Reversible ... - Wiley Online Library
WebbTNBC is highly invasive and prone to brain and lung metastasis, leading to a short survival time of about 13.3 months. The ineffective treatment of TNBC is partly due to lack of targeted molecular drugs [ 2, 3] and its notorious “cold” tumor microenvironment (TME) [ 3, … Webb11 feb. 2024 · Clinically, patients with TNBC have aggressive tumor biology, higher risk of recurrence, and poor prognosis. Given the absence of effective therapeutic targets, chemotherapy is the mainstay of management of TNBC but is associated with significant toxicity and low response rate, particularly in the metastatic setting. houghton basketball schedule
Penetrable Nanoplatform for “Cold” Tumor Immune …
Webb1 nov. 2024 · TNBC tumors displayed distinct ... provide a strong rationale for the use of EZH2-inhibtory agents as a strategy for restoring MHC-I expression in immune cold, PD-L1 negative, M-subtype tumors. Webb15 aug. 2024 · Our study represents a step toward personalized immunotherapy for patients with TNBC. Immune checkpoint inhibitors might be effective for "immune … Webb22 jan. 2024 · Triple-negative breast cancer (TNBC) due to lack of clear target and notorious "cold" tumor microenvironment (TME) is one of the most intractable and lethal … houghton basketball