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Webbför 16 timmar sedan · The purpose of this study was to develop a simple and high-throughput assay to identify compounds with antimicrobial activity against persister cells during a 24 h incubation period. Subsequently, this assay was used to screen a selection of small molecules with hypothesized anti-persister activity. Webb13 apr. 2024 · Target proteins and small molecule compounds targeting PSO were predicted in the connective map (cMAP) database. Molecular docking, MD simulation, and trajectory analysis were conducted to predict the binding of target proteins to compounds. Results. 1999 differentially expressed genes in PSO were obtained by differential analysis. WebbOur in-house designed CORE Library Stock of sp3-enriched, lead-like, small molecule screening compounds (8-digit IDs) offers more than 830,000 compounds. These high … canal to baltic sea