Nettet3. mai 2024 · Dolutegravir (DTG) monotherapy results in virologic failure and the development of DTG resistance. Here, we evaluated virologic outcomes of patients … Nettet12. feb. 2024 · Such a mono-drug regimen have significant advantages, including less side-effects and pill burden. The hypothesis that one powerful antiretroviral drug would be sufficient to maintain virological suppression, led to several trials comparing the virological efficacy of PI or INSTI monotherapy to traditional three-drug regimens (28, 30–33).
Guidelines for the Use of Antiretroviral Agents in HIV-1
Nettet24. jul. 2024 · Background: A high genetic barrier to resistance to the integrase strand transfer inhibitor (INSTI) dolutegravir has been reported in vitro and in vivo. We … Nettet13. apr. 2024 · Oral PI, NRTI, or INSTI with a two-NRTI backbone vs oral lead-in of cabotegravir 30 mg/day plus rilpivirine 25 mg/day for 4 weeks, followed by 600 mg of long-acting cabotegravir intramuscularly plus 900 mg long-acting rilpivirine intramuscularly once on week 4, followed by 400 mg long-acting cabotegravir intramuscularly plus 600 mg … heritance ahungalla images
Effect of Dolutegravir Functional Monotherapy on HIV-1 …
Nettet6. jul. 2016 · Lazerwith S et al. Discovery of GS-9883, an HIV-1 integrase strand transfer inhibitor (INSTI) with improved pharmacokinetics and in vitro resistance profile. ASM … Nettet11. feb. 2016 · These DRMs can reduce the activity of ARVs used in combination treatments with INSTI, increasing the risk of a functional INSTI monotherapy and explaining the emergence of INSTI resistance (Cahn ... NettetAu cours de ce travail, nous avons mis en évidence un nouveau mécanisme de résistance aux INSTI chez le VIH-2, l’insertion de 5 acides aminés après le codon 231 du gène de l’intégrase. heritance ahungalla sri lanka tripadvisor