Web13 de abr. de 2015 · HIF2α inhibitors suppress aberrant expression of HIF target genes in the vhl mutant zebrafish. vhl–/– zebrafish display the human VHL disease signature phenotypes of erythrocytosis and inappropriate vessel proliferation (refs. 21, 22, and Figure 4A ). In humans, HIF2α is a critical target of VHL tumor suppressor protein, and … Web1 de set. de 2024 · The observation that acute postnatal global ablation of Hif2a, but not Hif1a, results in anemia convincingly shows that Hif-2α is the main regulator of EPO synthesis in the adult mouse [61]. On the other hand, it was found that Hif-1α deficiency leads to impaired erythropoiesis during embryogenesis [ 62 ].
Targeting EPO and EPO receptor pathways in anemia and
Web上领英，在全球领先职业社交平台查看李乐啸的职业档案。李乐啸的职业档案列出了 2 个职位。上领英，查看李乐啸的完整档案，结识职场人脉和查看相似公司的职位。 Web8 de jan. de 2016 · Upon hypoxia, neuronal loss of Hif1a caused a significant increase in total Epo mRNA expression, while loss of Hif2a resulted in reduced expression as compared to WT controls (Figure 3(a)). It suggests that similar to other cell types, 38 neuronal Epo transcription is preferentially controlled by HIF-2 and not HIF-1. flushing imaging center
IJMS Free Full-Text Hypoxia Differently Affects TGF-β2 …
Webhypertensive male with heterozygous HIF2A c.1609G>A, mutation with Hb/Hct/Epo of 23/58.7/175 at diagnosis, developed a CVA with ongoing phlebotomy. An elevated Epo … Web3 de dez. de 2015 · We found that kidney or liver specific Epo overexpression resulting from stable HIF-2a DPM mutant is sufficient to develop erythrocytosis, while HIF-2a DPM … Web3 de nov. de 2016 · Clear cell Renal Cell Carcinoma (ccRCC) is characterized by VHL inactivation 1,2.Because no other gene is mutated as frequently, and VHL mutations are truncal 3, VHL inactivation is regarded as the governing event 4. VHL loss activates HIF-2, and constitutive HIF-2 restores tumorigenesis in VHL-reconstituted ccRCC cells 5.HIF-2 … flushing in animals