WebPublisher Summary. Transforming growth factor beta-1 (TGF β - 1) is the prototype and founding member of the TGF β superfamily. Members of the TGF β superfamily have important regulatory roles in a number of cellular functions, including proliferation, differentiation, chemotaxis, apoptosis, and tumor suppression. WebJun 1, 2024 · Meanwhile, the administration of a TGF-β inhibitor decreased HCC tumor growth by blocking the crosstalk between tumor and stroma [60]. It has also been reported that in MDA-MB-231 breast cancer cells, activation of the TGF-β/CTGF pathway alters the metabolism of CAFs with the induction of autophagy, glycolysis, and senescence [61].
Angiotensin II induces connective tissue growth factor …
WebNov 29, 2024 · Background: Lung epithelial cells play critical roles in idiopathic pulmonary fibrosis. Methods: In the present study, we investigated whether transforming growth … CTGF is associated with wound healing and virtually all fibrotic pathology. It is thought that CTGF can cooperate with TGF-β to induce sustained fibrosis and to exacerbate extracellular matrix production in association other fibrosis-inducing conditions. Overexpression of CTGF in fibroblasts promotes … See more CTGF, also known as CCN2 or connective tissue growth factor, is a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins (see also CCN intercellular signaling protein). … See more Members of the CCN protein family, including CTGF, are structurally characterized by having four conserved, cysteine-rich … See more • Ctgf/hcs24 CAESAR • CYR61 (CCN1) See more Knockout mice with the Ctgf gene disrupted die at birth due to respiratory stress as a result of severe chondrodysplasia. Ctgf-null mice also show defects in … See more • Human CTGF genome location and CTGF gene details page in the UCSC Genome Browser. See more opc weimann
TGF-β2刺激人Tenon囊成纤维细胞增殖，表达CTGF和合成Fn - 豆 …
WebFeb 1, 2024 · 结缔组织生长因子（ctgf）是继tgf-β乊后发现的又一个重要的促纤维化因子，被认为是tgf-β的下游作用元件以及纤维化进程的启动因子[2]，其作用主要表现为促进 … WebApr 11, 2024 · Transforming growth factor β (TGF-β) is an important signaling molecule which is expressed in three different isoforms in mammals (i.e. TGF-β1, -β2, and -β3).The interaction between TGF-β and its receptor triggers several pathways, which are classified into SMAD-dependent (canonical) and SMAD-independent (non-canonical) signaling, … Webtgf-β1是由淋巴细胞、巨噬细胞、血小板等合成并分泌的一类可调节细胞生长及分化的细胞因子，属于tgf家族[2-3]。 能诱导、促进间质细胞分化、增殖、分泌细胞外基质(ECM)相关成分，并能增加纤维连接蛋白及胶原蛋白量,是最强的致纤维化因子[4-5]。 opcweb/condeq/property/staff.aspx