Cisplatin kidney function

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August undefined, 2024

WebRenal function of cancer patients "fit" for Cisplatin chemotherapy: physician perspective Authors J Montoya 1 , H G Luna 2 , J R Amparo 2 , C Casasola 3 , G Cristal-Luna 2 Affiliations 1 Joey Montoya, MD, National … WebSep 1, 2014 · Acute kidney injury (AKI), previously called acute renal failure (ARF) , is defined as an abrupt onset of renal dysfunction ranging from minor loss of function to failure [7,8,9]. AKI is a common clinical complication that develops in approximately 4%–7% of hospitalized patients each year and the prognosis can be poor [ 10 , 11 ].

Drug-Induced Nephrotoxicity AAFP

WebFindings: In vivo, after celastrol treatment, cisplatin-induced kidney injury was significantly ameliorated as shown by the improvement of renal function (BUN, serum creatinine, and cystatin C), kidney morphology (PAS staining) and oxidative stress (MDA) and the suppression of renal tubular injury markers of KIM-1 and NGAL. WebSep 15, 2008 · The kidney maintains or autoregulates intraglomerular pressure by modulating the afferent and efferent arterial tone to preserve GFR and urine output. For instance, in patients with volume... highland games englisch referat

Significance of downregulation of renal organic cation transporter ...

WebAbstract Cisplatin has been a mainstay of cancer chemotherapy since the 1970s. Despite its broad anticancer potential, its clinical use has regularly been constrained by kidney … WebCisplatin for injection has been administered at 75 mg/m. 2 . to 100 mg/m. intravenously per cycle once every 3 to 4 weeks on Day 1. Other doses and combination regimens have been used. 2.4 Advanced Bladder Cancer . Cisplatin for injection has been administered at 50 mg/m. 2 . to 70 mg/m. intravenously per cycle once every 3 to 4 weeks. WebApr 12, 2024 · GFR allows a correct assessment of kidney function in patients with cancer undergoing cisplatin therapy. Abbreviations: BSA, body surface area; CKD-EPI, chronic kidney disease epidemiology collaboration; CRF, chronic renal failure; GFR, estimated-glomerular filtration rate; FPA, furanpropanoic acid; PAH, P-Amminoippurate; uCrCl, … highland games disziplinen liste

Advanced Bladder Cancer and Impaired Renal Function - Medscape

Biomolecules Free Full-Text Cisplatin-Induced Kidney Toxicity ...

WebOct 1, 2024 · Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney injury (AKI). Patients who develop AKI have an increased risk of mortality and are more likely to develop chronic kidney disease (CKD). WebApr 14, 2024 · Since HK-2-cells-generated-Abs, both by cisplatin or upon UV light exposure, can induce apoptosis in HK-2 cells, the purpose of this work was to study their metabolome and therein find the molecular features which help us to unravel the mechanisms of that phenomenon. highland games disciplinesWebJun 18, 2024 · The current use of cisplatin in regimens involving pre and posthydration with careful monitoring of diuresis in the treatment of testicular tumors is associated with renal … highland games dfw

"WebAcute kidney injury is a known side effect of cisplatin treatment, and kidney dysfunction results in the accumulation of uremic toxins in the serum. The present study aimed to investigate whether indoxyl sulfate (IS), a representative uremic toxin, affects the pathophysiology of EOC. " - Cisplatin kidney function

Cisplatin kidney function

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WebMar 1, 2024 · Acute kidney injury (AKI) is the main obstacle that limits the use of cisplatin in cancer treatment. Proton pump inhibitors (PPIs), the most commonly used class of medications for gastrointestinal complications in cancer patients, have been reported to cause adverse renal events. However, the effect … WebFeb 16, 2024 · Common side effects of cisplatin may include: hearing problems; kidney problems; numbness or tingling; nausea, vomiting; or. bone marrow suppression. This is …

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WebSep 2, 2024 · The same protective function could also be found with the expression of Nox4 and Sod2 mRNA (Figures 5D,E). To evaluate the ROS level in the cells, a DHE fluorescent probe was used. ... MLT alleviates cellular apoptosis after kidney injury caused by cisplatin, inhibiting the NF-κB–mediated inflammatory response and RIPK1/RIPK3 … WebJan 3, 2024 · Assessment of kidney function; Bleomycin-induced lung injury; Chemotherapy and radiation-related hemorrhagic cystitis in cancer patients; …

WebKidney toxicity. Effects on kidney function are dose related, observed 10-20 days after therapy, and are generally reversible. Ototoxicity hearing loss, ringing in the ears. …

WebApr 25, 2014 · Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and … WebOrganic cation transporter in proximal tubular epithelial cells play an important role in the elimination of cisplatin. 3 The multi antimicrobial extrusion protein (MATE1/SLC47A1) is …

WebAug 22, 2015 · Cisplatin has a well-established role in the treatment of broad spectrum of malignancies; however its use is limited because of cisplatin-induced nephrotoxicity (CIN) which can be progressive in more than 50% of cases.

WebFeb 23, 2024 · Instead of relying on an absolute renal function threshold of 60 mL/min, which excludes a significant proportion of patients with MIBC from receiving cisplatin, … highland games disciplines englishWebOct 14, 2024 · Cisplatin is an inorganic platinum-based drug that was FDA approved as an anticancer agent in 1978.1It is a standard therapy used to treat many solid organ cancers.2The major mechanism of action of cisplatin involves binding DNA and forming adducts, leading to apoptosis or cell cycle arrest. highland games doornWebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe … how is enriched corn meal madeWebJun 11, 2024 · Vagus nerve stimulation even after injury ameliorates cisplatin-induced nephropathy via reducing macrophage infiltration Scientific Reports Article Open Access Published: 11 June 2024 Vagus... highland games dunedinWebJan 11, 2024 · Trials evaluating cisplatin-eligible patients use renal function thresholds ranging from 40 ml/min to 60 ml/min, whereas trials evaluating cisplatin-ineligible patients employ overlapping... highland games dunedin flWebMar 20, 2024 · The reality of cisplatin-induced acute kidney injury (CIA) and its effects on long-term renal function remain unclear. The aim of this study was to investi Impact of … highland games englishWebMar 23, 2024 · Here, we postulated that systemically delivered rapamycin perfluorocarbon nanoparticles (PFC NP) could reach the injured kidneys at sufficient and sustained concentrations to mitigate cisplatin-induced acute kidney injury … how is enriched wheat flour made