Cisplatin chemistry

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August undefined, 2024

WebIn the 1960s the drug cis-platin was discovered, which has been extremely effective in treating a number of different types cancer such as testicular, ovarian, cervical, breast, lung and brain cancer. Cancer cells grow and replicate much faster than normal cells. Cis-platin is a square planar molecule that has a geometric isomer with the side ... WebLTTs minimise cisplatin-induced DNA damage and evade apoptosis by increased expression of anti-apoptotic factors. The observed diversity among the four LTTs highlights the complexity of cisplatin resistance mechanisms even within one tumour entity, explaining heterogeneity in patient responses to chemotherapy. ... Chemistry 2016, 22, 8943 ...

Cisplatin in cancer therapy: molecular mechanisms of action

WebThe microstructure and properties of metal ion-assisted cisplatin-loading SLNs were investigated by infra-red spectroscopy, fluorescence spectroscopy and zetasizer. The reactions of hydrogenated soybean lecithin with Zn(2+), Cu(2+), Mn(2+ )and Mg(2+ )have been detected; the mechanism for higher drug encapsulation efficiency (EE) has been ... WebOct 5, 2014 · Cisplatin has a molecular weight of 301.1 gm/mol, a density of 3.74 g/cm 3, a melting point of 270° C, a log K ow of -2.19 and a water solubility of 2.53 g/L at 25° … fabielly bellagamba ramos

Intersection of Inorganic Chemistry and Nanotechnology for the …

WebApr 15, 2024 · The treatment was well tolerated only he developed grade 2 mucositis and weight loss associated with cisplatin [ duration of treatment to reactions onset not stated … WebThe high stability of PTCG NPs during circulation stems from their strong metal-polyphenol coordination interactions, and efficient drug release is realized after cellular internalization. The activated cisplatin elevates the intracellular H 2 O 2 level through cascade reactions. WebSpecifically, the following ionic compounds present in the nutrient medium formed oxidizing agents after electrolysis with platinum electrodes: ammonium sulfate ( (NH 4) 2 SO 4 ); ammonium carbonate ( (NH 4) 2 CO 3 ); ammonium chloride (NH 4 Cl); and other chlorides. fabics gym

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Cisplatin 9. The Discovery - Chemistry LibreTexts

WebThe shape of the cisplatin molecule is square and flat. Its covalent bonds readily exchange with other ligands, including even water. In the aqueous environment of the body, the … WebApr 8, 2024 · 1 Beijing National Laboratory for Molecular Sciences; CAS Key Laboratory of Analytical Chemistry for Living Biosystems; National Centre for Mass Spectrometry in Beijing, Institute of Chemistry, ... (NH3)(thiazole)] (trans-PtTz) toward HeLa cells to a similar level of cisplatin, contributable to retarding the repair of 1,3-trans-PtTz crosslinked ... fabido tek osulfwegWebOne of the first known coordination compounds was Peyrone’s Chloride (also known as cis-diamminedichloroplatinum (II), or cis-DDP), first reported in 1845. This compound was not fully understood until 1893, when Alfred Werner deduced its structure and described cis-DDP and its trans isomer in a landmark paper. hindu dan islam

"WebSep 30, 2024 · Cisplatin resistance in tumor cells is known mainly due to the reduced accumulation of platinum ions by efflux, detoxification by intracellular GSH, and nucleotide excision repair machinery-mediated nuclear DNA repair. " - Cisplatin chemistry

Cisplatin chemistry

A Metal-Polyphenol-Coordinated Nanomedicine for Synergistic …

WebCisplatin coordinates to DNA mainly through certain nitrogen atoms of the DNA base pairs; these nitrogen atoms (specifically, the N7 atoms of purines) are free to coordinate to cisplatin because they do not form hydrogen bonds with any other … WebOct 5, 2014 · Cisplatin, cisplatinum, or cis-diamminedichloroplatinum (II), is a well-known chemotherapeutic drug. It has been used for treatment of numerous human cancers including bladder, head and neck, lung, ovarian, and testicular cancers. It is effective against various types of cancers, including carcinoma …

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WebHypoxia can induce chemoresistance, which is a significant clinical obstacle in cancer therapy. Here, we assessed development of hypoxia-induced chemoresistance (HICR) against free versus polymeric cisplatin micelles in a triple negative breast cancer cell line, MDA-MB-231. We then explored two strategies for the modulation of HICR against … WebCisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug Wiley 30 years after its discovery as an antitumor agent, cisplatin represents today one of the most …

WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 … WebCisplatin is a chemotherapy medication used to treat a number of cancers. [2] These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. [2] It is given by injection into a vein. [2]

WebCisplatin or (SP-4-2)-diamminedichloridoplatinum(II) is one of the most potential and widely used drugs for the treatment of various solid cancers such as testicular, … WebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), …

WebJan 28, 2024 · In this study, we sought to provide a comprehensive review of the current state of the science highlighting the use of cisplatin in cancer therapy, with a special emphasis on its molecular mechanisms of action, and treatment modalities including the combination therapy with natural products.

Webtrans-Platinum(II) diamminedichloride Cl2H6N2Pt+2 CID 441203 - structure, chemical names, physical and chemical properties, classification, patents, literature ... hindu dand fabi bozenWebThis book compiles in six Parts the various aspects of chemistry, biochemistry, biology, pharmacology, and medicine relevant to cisplatin, describing new links that suggest how … hindu dateWebCisplatin: chemistry, distribution and biotransformation Authors D F Long , A J Repta PMID: 7016212 DOI: 10.1002/bdd.2510020102 Abstract A review of the use of cisplatin … hindu dataWeb2 days ago · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In particular, the … hindu data pointWebIn water, the antineoplastic drug cisplatin, cis- [PtCl2 (NH3)2] (1) hydrolyses slowly to the aqua complexes cis- [Pt (NH3)2Cl (H2O)]+ (2) and, to a small extent, cis- [Pt (NH3)2 (H2O)2]2+ (3), which are thought to play an important role in the metabolism of cisplatin. fabien azziWebJul 1, 2024 · Cisplatin is one of the best and first metal-based chemotherapeutic drugs (see Fig. 1 for 3D structure of cisplatin) [10], [287]. It is reported that ∼2 billion U.S. dollars of platinum-based anticancer drugs are sold worldwide [6], [7] and nearly about 50% of all patients are treated with cisplatin [8]. fabien azoulay gbl