WebApr 6, 2024 · In this study, we utilized CRISPR-Cas9 ribonucleoproteins (RNPs) to disrupt CISH and CBLB genes in isolated peripheral blood NK cells from healthy donors. CD70 was also knocked out on CAR NK cells to avoid fratricide due to CD70 expression on activated NK cells and specifically target CD70 overexpression on renal cell carcinoma (RCC) …
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WebApr 8, 2024 · Presented jointly with CRISPR Therapeutics: Title: CBLB, CISH and CD70 multiplexed gene knockout with CRISPR/Cas9 enhances cytotoxicity of CD70-CAR NK cells and provides greater resistance to TGF-β for cancer immunotherapy Session Category: Immunology Session Title: Preclinical Immunotherapy Abstract Number: 5512 WebApr 7, 2024 · 自然杀伤细胞 (Natural Killer Cell)是人体固有的一类免疫细胞,大家都简称其为NK细胞,它具有强大的免疫杀伤功能和免疫记忆能力。随着嵌合抗原受体T细胞( CAR-T) 技术的兴起,科学家将目光转移到同为免疫细胞的NK细胞,对其CAR修饰潜力进行挖掘。CAR-NK细胞的研发沿袭了经典的CAR-T细胞研发思路,却又 ... philiposes kitchen
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WebApr 12, 2024 · Compared to CARs developed for T cells and transferred into NK cells, Shoreline's NK-optimized CARs yield significantly increased tumor killing activity. "The presentations at AACR 2024 on our CISH-KO iNK cells and natural killer-optimized CARs demonstrate our sophisticated expertise in iPSC differentiation, gene editing, and CAR … WebFeb 4, 2024 · CISH KO was performed using ribonucleoprotein (RNP) complex, in both NT and CAR-NK cells (for details, see supplemental Methods, available on the Blood Web … WebCISH gene-knockout CD70-CAR NK cells could be produced efficiently and exhibited extended persistence in culture. After engineering and expansion, CD70-CAR … truist baseball stadium charlotte nc